Celesia G G, Polcyn R D, Holden J E, Nickles R J, Gatley J S, Koeppe R A
Electroencephalogr Clin Neurophysiol. 1982 Sep;54(3):243-56. doi: 10.1016/0013-4694(82)90174-2.
Visual evoked potentials (VEPs) and visual evoked spectrum array (VESA) to flashes and pattern-reversal were correlated with regional cerebral blood flow (rCBF) or local cerebral glucose metabolism in 4 hemianopsic patients and one subject with cortical blindness. Normal VEPs, topographical distribution and occipital rCBF were noted in hemianopsic patients with macular sparing. A dissociation of topographical distribution of VEPs to flashes and pattern-reversal was demonstrated in one patient with hemianopsia and macular splitting. In this case, rCBF showed unilateral activation of visual areas 17, 18 and 19 of the cortex. The distribution of surface-recorded potentials reflected the complex interaction of electrical field potentials within at least 3 cortical areas rather than volume transmission of striate dipoles alone. VEPs were preserved in a cortically blind patient. rCBF and local cerebral glucose metabolism revealed a functioning island of occipital cortex that most likely represented the generator of the VEP. The combination of VEP and PET permits the correlation of electrophysiological events with the visualization of cortical areas presumably activated by the same visual stimulus.
在4例偏盲患者和1例皮质盲患者中，将闪光视觉诱发电位（VEP）和视觉诱发频谱阵列（VESA）以及图形翻转视觉诱发电位与局部脑血流（rCBF）或局部脑葡萄糖代谢进行了相关性研究。在黄斑保留的偏盲患者中观察到正常的VEP、地形图分布和枕叶rCBF。在1例偏盲伴黄斑分裂的患者中，显示出闪光视觉诱发电位和图形翻转视觉诱发电位地形图分布的分离。在该病例中，rCBF显示皮质视觉区17、18和19的单侧激活。表面记录电位的分布反映了至少3个皮质区域内电场电位的复杂相互作用，而不仅仅是纹状偶极子的容积传导。VEP在1例皮质盲患者中得以保留。rCBF和局部脑葡萄糖代谢显示枕叶皮质有一个功能岛，很可能代表了VEP的发生器。VEP和正电子发射断层扫描（PET）的结合使得电生理事件能够与推测由相同视觉刺激激活的皮质区域的可视化相关联。
