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Immunoregulatory effects of covalent antigen-antibody complexes. IV. Priming and tolerance in T-dependent responses.共价抗原-抗体复合物的免疫调节作用。IV. T细胞依赖性反应中的致敏与耐受
Immunology. 1982 Aug;46(4):809-17.
2
Immunoregulatory effects of covalent antigen-antibody complexes. III. Enhancement or suppression depending on the time of administration of complex relative to a T-independent antigen.共价抗原-抗体复合物的免疫调节作用。III. 相对于非T细胞依赖性抗原，根据复合物给药时间的不同而产生的增强或抑制作用。
Immunology. 1981 Feb;42(2):355-62.
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C3- and T-cell-dependent adjuvant activity of in vivo formed immune complexes.体内形成的免疫复合物的C3和T细胞依赖性佐剂活性。
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The generation of memory cells. V. Preferential priming of IgG1 B memory cells by immunization with antigen IgG2 antibody complexes.记忆细胞的产生。V. 用抗原IgG2抗体复合物免疫对IgG1 B记忆细胞的优先启动。
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The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response.记忆细胞的产生。IV. 用抗原-抗体复合物进行免疫可加速二次免疫应答中B记忆细胞的发育、生发中心的形成以及抗体亲和力的成熟。
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引用本文的文献

1
Allergic bronchial asthma due to Dermatophagoides pteronyssinus hypersensitivity can be efficiently treated by inoculation of allergen-antibody complexes.由屋尘螨过敏引起的过敏性支气管哮喘可通过接种变应原 - 抗体复合物得到有效治疗。
J Clin Invest. 1990 Apr;85(4):1024-35. doi: 10.1172/JCI114532.

本文引用的文献

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Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.抗体产生的特异性抑制。II. 少量蛋白质抗原诱导成年小鼠麻痹
Immunology. 1962 May;5(3):378-88.
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Elimination of 131-I-labelled protein antigens from the circulation of the mouse.从小鼠循环系统中清除¹³¹-I标记的蛋白质抗原。
Immunology. 1960 Oct;3(4):289-95.
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Induction of T and B cell immunity by anti-idiotypic antibody.抗独特型抗体诱导T细胞和B细胞免疫
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Immunoregulatory effects of covalent antigen-antibody complexes. III. Enhancement or suppression depending on the time of administration of complex relative to a T-independent antigen.共价抗原-抗体复合物的免疫调节作用。III. 相对于非T细胞依赖性抗原，根据复合物给药时间的不同而产生的增强或抑制作用。
Immunology. 1981 Feb;42(2):355-62.
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Idiotypic regulation by isologous monoclonal anti-idiotope antibodies.同源单克隆抗独特型抗体的独特型调节
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6
Regulation of the immune response. IV. Antibody-mediated suppression of the immune response to haptens and heterologous erythrocyte antigens in vitro.免疫反应的调节。IV. 抗体介导的体外对半抗原和异种红细胞抗原免疫反应的抑制
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Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.使用微溶性氯酰胺1,3,4,6-四氯-3a,6a-二苯基甘脲进行蛋白质和细胞膜碘化
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Immunoregulatory effects of a covalent antigen-antibody complex.共价抗原-抗体复合物的免疫调节作用
Nature. 1979 Oct 11;281(5731):488-90. doi: 10.1038/281488a0.
9
Immunoregulation by covalent antigen-antibody complexes. II. Suppression of a T-cell independent anti-hapten response.共价抗原-抗体复合物介导的免疫调节。II. 对T细胞非依赖性抗半抗原反应的抑制
Immunology. 1979 Oct;38(2):325-31.
10
Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice.抗独特型诱导成年BALB/c小鼠对磷酸胆碱反应中辅助性细胞功能的调节。
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共价抗原-抗体复合物的免疫调节作用。IV. T细胞依赖性反应中的致敏与耐受

Immunoregulatory effects of covalent antigen-antibody complexes. IV. Priming and tolerance in T-dependent responses.

作者信息

Tite J P, Morrison C A, Taylor R B

出版信息

Immunology. 1982 Aug;46(4):809-17.

PMID:6179858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555471/
Abstract

Stable, covalently bonded, monomeric complexes of rabbit anti-NAP (4-azido-2-nitrophenyl) antibodies and NAP-bovine pancreatic ribonuclease (RNase), when injected into mice, prime the subsequent response to a soluble challenge of RNase. This effect is shown to be dependent on an intact Fc portion of the rabbit antibody and not simply due to foreign determinants recognized on the latter. A study of the kinetics of elimination of radioiodinated complexes from the serum indicates that the generation of a primary anti-rabbit IgG response and subsequent clearance of the complex leads to priming of the anti-RNase response. If mice are previously rendered tolerant to rabbit IgG or the complexes are ultracentrifuged, the priming to RNase is often abolished and tolerance may be induced.

摘要

兔抗-NAP（4-叠氮基-2-硝基苯基）抗体与NAP-牛胰核糖核酸酶（RNase）形成的稳定、共价结合的单体复合物，注射到小鼠体内时，能引发随后对RNase可溶性攻击的反应。这种效应被证明依赖于兔抗体完整的Fc部分，而不仅仅是由于识别后者上的外来决定簇。对血清中放射性碘化复合物清除动力学的研究表明，初次抗兔IgG反应的产生以及随后复合物的清除会导致抗RNase反应的引发。如果小鼠先前已对兔IgG产生耐受，或者复合物经过超速离心，对RNase的引发作用通常会消失，并且可能会诱导耐受。