Stewart R V, Dincsoy H P
Am J Clin Pathol. 1982 Sep;78(3):293-8. doi: 10.1093/ajcp/78.3.293.
One hundred forty-three liver biopsy specimens were evaluated by light microscopy for giant mitochondria (GM), and were correlated with a variety of histological and clinical parameters. GM were found in 57% of the biopsy specimens. In alcoholic liver diseases, GM are mostly round in shape, are centrilobular in distribution, and frequently coexist with Mallory bodies. The frequency of hepatocytes containing GM in alcoholic liver disease is the highest of all groups. In nonalcoholic liver diseases, GM are round or needle-shaped, distributed randomly or in the periphery of the hepatic lobules, and the frequency of hepatocytes containing GM is less than that in alcoholic liver disease. These features are useful in separating alcoholic from nonalcoholic liver diseases. While GM appear to represent early hepatocellular injury, certain factors appear to influence GM formation in nonalcoholic liver diseases, including high alcohol consumption in both alcoholic and nonalcoholic liver diseases, fatty change, under-nutrition or abnormal nutrition, and upper gastrointestinal tract disorders.
对143份肝活检标本进行光学显微镜检查以评估巨型线粒体（GM），并将其与各种组织学和临床参数进行关联分析。在57%的活检标本中发现了GM。在酒精性肝病中，GM大多呈圆形，分布于小叶中央，且常与马洛里小体共存。酒精性肝病中含有GM的肝细胞频率在所有组中最高。在非酒精性肝病中，GM呈圆形或针状，随机分布或分布于肝小叶周边，含有GM的肝细胞频率低于酒精性肝病。这些特征有助于区分酒精性肝病和非酒精性肝病。虽然GM似乎代表早期肝细胞损伤，但某些因素似乎会影响非酒精性肝病中GM的形成，包括酒精性和非酒精性肝病中的高酒精摄入量、脂肪变性、营养不足或营养异常以及上消化道疾病。
