Daszuta A, Hery F, Faudon M
Brain Res Bull. 1984 May;12(5):559-63. doi: 10.1016/0361-9230(84)90172-2.
"In vitro," 3H-5-HT and 3H-5-HIAA newly synthesized from 3H-TRP are measured in the caudate nucleus and the hippocampus of C57BL and BALBc mice. Higher synthesis, utilization and release are to be found in C57BL than in BALBc strain. In the hippocampus of C57BL this higher synthesis is due both to higher tryptophan hydroxylase activity and to higher tryptophan uptake ability. But in the caudate nucleus the initial accumulation of tryptophan is similar in both strains. Finally the two forms of monoamine oxidase (A and B) show also similar activities in both strain. These data will be compared to those obtained at the nerve cell body level in the paper (II).
在体外，测量了从3H-色氨酸新合成的3H-5-羟色胺和3H-5-羟吲哚乙酸在C57BL和BALBc小鼠的尾状核和海马体中的含量。发现C57BL品系的合成、利用和释放比BALBc品系更高。在C57BL品系的海马体中，这种更高的合成既归因于更高的色氨酸羟化酶活性，也归因于更高的色氨酸摄取能力。但在尾状核中，两种品系的色氨酸初始积累相似。最后，两种形式的单胺氧化酶（A和B）在两种品系中的活性也相似。这些数据将与本文（II）在神经细胞体水平获得的数据进行比较。
