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[胃交感神经切除术:猪应激性胃黏膜损伤的有效预防措施]

[Sympathectomy of the stomach: an effective preventive measure in stress-induced gastric mucosa lesions in swine].

作者信息

Hottenrott C, Seufert R, Kühne F, Gerstenbergk L

出版信息

Chir Forum Exp Klin Forsch. 1977 Apr:221-3.

PMID:618305
Abstract

15 mini-pigs were bled to a mean aortic blood-pressure of 40 mm Hg, which was sustained for 3 hours. 2 groups were studied: Control-Group: Shock alone without splanchnicectomy (n = 8); Test-Group: Shock after splanchnicectomy 14 days previously (n = 7). In all animals a stimulated gastric secretion test was performed 3 days before and 8 days after this operation. All animals of the control-group showed severe gastric mucosal lesions after shock. Piglets with splanchnicectomy (test-group), conversely, developed no (5 animals) or only minor changes (2 animals). The efficiency of splanchnicectomy was proved by a stimulated gastric secretion test: Basal acid output did not change after operation, peak acid output however increased significantly. This study in piglets shows, that splanchnicectomy of the stomach prevents gastric stress-lesions almost completely.

摘要

将15只小型猪放血,使平均主动脉血压降至40毫米汞柱,并持续3小时。研究了2组:对照组:单纯休克,未进行内脏切除术(n = 8);试验组:14天前进行内脏切除术后休克(n = 7)。在所有动物中,在该手术前3天和术后8天进行了刺激胃分泌试验。对照组所有动物在休克后均出现严重胃黏膜损伤。相反,进行了内脏切除术的仔猪(试验组)未出现(5只动物)或仅出现轻微变化(2只动物)。通过刺激胃分泌试验证明了内脏切除术的效果:术后基础胃酸分泌量未改变,但高峰胃酸分泌量显著增加。对仔猪的这项研究表明,胃的内脏切除术几乎可以完全预防胃应激性损伤。

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