Levine B A, Gaskill H V, Sirinek K R
J Trauma. 1983 Apr;23(4):278-84. doi: 10.1097/00005373-198304000-00002.
Prior reports have shown the protective effect of splanchnicectomy against stress-related gastric mucosal injury. The present study evaluated the possible relation of such cytoprotection with an effect on gastric acid secretion and gastric mucosal blood flow (GMBF). Miniature swine were divided into sham-operated and celiac ganglionectomy groups. Three weeks postoperatively all animals underwent hemorrhagic shock stress. Neither basal nor peak gastric acids was affected by splanchnicectomy or sham operations. Significant GMBF reductions occurred in early shock in both treatment groups. In the sham pigs these GMBF reductions persisted, while in the splanchnicectomy pigs, GMBF in late shock returned to normotensive levels. These results demonstrate that splanchnicectomy: 1) has no effect on basal or maximally stimulated gastric acid secretion, and 2) is associated with reestablishment of GMBF to preshock levels during sustained hypotension. These results indicate a beneficial effect on GMBF as a factor in gastric cytoprotection afforded by splanchnicectomy.
先前的报道显示了内脏切除术对与应激相关的胃黏膜损伤的保护作用。本研究评估了这种细胞保护作用与胃酸分泌及胃黏膜血流量（GMBF）之间的可能关系。小型猪被分为假手术组和腹腔神经节切除术组。术后三周，所有动物均经历失血性休克应激。内脏切除术或假手术对基础胃酸和胃酸峰值均无影响。两个治疗组在休克早期GMBF均显著降低。在假手术猪中，这些GMBF降低持续存在，而在内脏切除术猪中，休克后期GMBF恢复到正常血压水平。这些结果表明，内脏切除术：1）对基础胃酸分泌或最大刺激胃酸分泌无影响；2）与在持续性低血压期间将GMBF恢复到休克前水平有关。这些结果表明，内脏切除术对GMBF具有有益作用，这是其提供胃细胞保护的一个因素。
