Campo M, Chiavaro I, Canfarotta C, Stivala F, Berrardini A
J Immunopharmacol. 1982;4(1-2):127-37. doi: 10.3109/08923978209031080.
The data of this experiment show that Levamisole moderately stimulates T-lymphocyte proliferation and efficiency in vitro and methisoprinol markedly does so when both drugs act in combination with PHA in subjects with severely impaired cell-mediated responsiveness, whereas they do not exert any effect on lymphocytes in normal subjects. B-lymphocyte in vitro responsiveness does not appear to be affected by the immunomodulators, except for some cases of cancer of the stomach wherein B-lymphocyte responsiveness is stimulated in vitro by Levamisole and more evidently by Methisoprinol. These data support the use of Methisoprinol or Levamisole in therapy, and further investigations regarding the mechanisms whereby they might act and the dose-effect relationship which might show to be important for the type of desired immunomodulation would appear appropriate.
本实验数据表明，左旋咪唑在体外适度刺激T淋巴细胞增殖及其效能，而美西异丁嗪在与PHA联合作用于细胞介导反应严重受损的受试者时，能显著刺激T淋巴细胞增殖及其效能，然而它们对正常受试者的淋巴细胞无任何作用。体外B淋巴细胞反应性似乎不受免疫调节剂影响，但在某些胃癌病例中，左旋咪唑能在体外刺激B淋巴细胞反应性，美西异丁嗪的刺激作用更明显。这些数据支持在治疗中使用美西异丁嗪或左旋咪唑，进一步研究它们可能的作用机制以及对所需免疫调节类型可能很重要的剂量效应关系似乎是合适的。
