Blankenhorn D H, Brooks S H, Selzer R H, Barndt R
Circulation. 1978 Feb;57(2):355-61. doi: 10.1161/01.cir.57.2.355.
The rate of change of femoral atherosclerosis has been determined in 25 treated hyperlipoproteinemic patients. There were 13 Type II patients and 12 Type IV patients. Serial angiograms had been performed at an interval averaging 13 months. Film densities were analyzed by digigal image processing to yield a computer estimate of atherosclerosis (CEA). Serial measurements of CEA on each patient were used to determine atherosclerosis percent change per month in that patient. CEA percent change per month was significantly correlated ;ith triglyceride and cholesterol level. Lower lipid levels were associated with more rapid regression. When hyperlipoproteinemic types were considered separately, significant single correlates were confined to Type IV. Triglyceride level and CEA/age significantly predicted atherosclerosis change rate and accounted for 72% of the variability observed in Type IV patients.
已对25例接受治疗的高脂血症患者的股动脉粥样硬化变化率进行了测定。其中有13例II型患者和12例IV型患者。已每隔平均13个月进行系列血管造影。通过数字图像处理分析胶片密度，以得出动脉粥样硬化的计算机估计值（CEA）。对每位患者的CEA进行系列测量，以确定该患者每月动脉粥样硬化的百分比变化。每月CEA百分比变化与甘油三酯和胆固醇水平显著相关。较低的血脂水平与更快速的消退相关。当分别考虑高脂血症类型时，显著的单一相关性仅限于IV型。甘油三酯水平和CEA/年龄显著预测了动脉粥样硬化变化率，并占IV型患者观察到的变异性的72%。
