Phillips K, Arffa R, Cintron C, Rose J, Miller D, Kublin C L, Kenyon K R
Arch Ophthalmol. 1983 Apr;101(4):640-3. doi: 10.1001/archopht.1983.01040010640024.
Albino rabbits were treated four or six times daily with 1% prednisolone acetate, 1% medroxyprogesterone acetate, or a control vehicle, after one of three conditions. First, after 3-mm linear perforating stromal incisions; drugs were given for seven days, and wound bursting strength was determined. Prednisolone suppressed wound tensile strength by 20%; medroxyprogesterone suppressed it by 11%. Second, after trephination, drug administration for 14 days decreased collagen formation in the scar buttons by 43% in the prednisolone-treated group and 39% in the medroxy-progesterone-treated group. Third, after thermal burns; when drug application followed the burn immediately, deep ulceration or perforation developed in 85% of the controls, in none of the prednisolone-treated group, and in 17% of the medroxyprogesterone-treated group. When drug delivery was withheld until day 6, severe ulceration developed in 44% of both groups. In both experiments, stromal neovascularization was markedly suppressed by prednisolone, but only moderately decreased by medroxyprogesterone.
白化兔在三种情况之一后，每天接受4次或6次1%醋酸泼尼松龙、1%醋酸甲羟孕酮或对照赋形剂的治疗。首先，在进行3毫米线性穿透性基质切口后；给药7天，并测定伤口破裂强度。泼尼松龙使伤口抗张强度降低20%；甲羟孕酮使其降低11%。其次，在环钻术后，给药14天，泼尼松龙治疗组瘢痕钮扣中的胶原形成减少43%，甲羟孕酮治疗组减少39%。第三，在热烧伤后；当烧伤后立即用药时，85%的对照组出现深度溃疡或穿孔，泼尼松龙治疗组无一出现，甲羟孕酮治疗组有17%出现。当药物给药推迟到第6天时，两组均有44%出现严重溃疡。在这两个实验中，泼尼松龙显著抑制基质新生血管形成，而甲羟孕酮仅使其适度减少。
