Fernandez L A, Fox R A
Clin Exp Immunol. 1980 Sep;41(3):527-32.
The effect of lithium on the human immune system is unknown. We studied lymphocyte responses to mitogens and their ability to produce lymphokines in four patients before and during lithium therapy. We found that with time, lithium increased lymphocyte responses to mitogens (PHA and PWM) and lymphokine production was altered from migration stimulation factor to migration inhibition factor. Although the exact mechanism is unknown, we propose that lithium has an effect on the suppressor cell system.
锂对人体免疫系统的影响尚不清楚。我们研究了4例患者在锂治疗前及治疗期间淋巴细胞对丝裂原的反应及其产生淋巴因子的能力。我们发现，随着时间的推移，锂增加了淋巴细胞对丝裂原（PHA和PWM）的反应，并且淋巴因子的产生从迁移刺激因子转变为迁移抑制因子。尽管确切机制尚不清楚，但我们认为锂对抑制细胞系统有影响。
