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Pharmacologic effects in man of a specific serotonin-reuptake inhibitor.

作者信息

Lemberger L, Rowe H, Carmichael R, Oldham S, Horng J S, Bymaster F P, Wong D T

出版信息

Science. 1978 Jan 27;199(4327):436-7. doi: 10.1126/science.619465.

Abstract

Fluoxetine (Li-ly 110140) caused a 63 percent inhibition of [3H]serotonin uptake into platelets obtained from normal volunteers to whom the drug was administered daily for 7 days. This dose had no effect on the usual pressor response produced by injections of norepinephrine or tyramine.

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