系统性红斑狼疮患者体内存在针对狒狒内源性病毒的RNA依赖性DNA聚合酶抗体的证据。
Evidence in patients with systemic lupus erythematosus of the presence of antibodies against RNA-dependent DNA polymerase of baboon endogenous virus.
作者信息
Okamoto T, Tamura T, Takano T
出版信息
Clin Exp Immunol. 1983 Dec;54(3):747-55.
Abstract
Immunoglobulin G (IgG) in six out of 30 patients with systemic lupus erythematosus (SLE) strongly inhibited the activity of RNA-dependent DNA polymerase (RDPase) of baboon endogenous virus, M7, while IgG obtained from scleroderma patients, rheumatoid arthritis patients and normal subjects was less reactive. Experiments with anti-human IgG and with IgG F (ab')2-bound immunoaffinity columns indicated that the inhibition of RDPase was antibody-mediated. The RDPase inhibiting activity of SLE IgG was considered not to be due to cross-reactions of anti-nuclear antibodies including anti-DNA, anti-ribonucleoprotein, anti-Sm and anti-SS.B antibodies. SLE IgG preferably inhibited the RDPase activity of baboon endogenous virus and a feline endogenous virus, RD114. These findings support the hypothesis that retrovirus(es) might be involved in SLE.
摘要
在30例系统性红斑狼疮（SLE）患者中，有6例患者的免疫球蛋白G（IgG）强烈抑制狒狒内源性病毒M7的RNA依赖性DNA聚合酶（RDPase）活性，而从硬皮病患者、类风湿关节炎患者和正常受试者中获得的IgG反应性较低。用抗人IgG和IgG F（ab'）2结合的免疫亲和柱进行的实验表明，RDPase的抑制是由抗体介导的。SLE IgG的RDPase抑制活性被认为不是由包括抗DNA、抗核糖核蛋白、抗Sm和抗SS.B抗体在内的抗核抗体的交叉反应引起的。SLE IgG优先抑制狒狒内源性病毒和猫内源性病毒RD114的RDPase活性。这些发现支持逆转录病毒可能与SLE有关的假说。
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