柴油尾气颗粒中二硝基芘的鉴定。它们可能作为主要诱变剂存在。

Identification of dinitropyrenes in diesel-exhaust particles. Their probable presence as the major mutagens.

作者信息

Nakagawa R, Kitamori S, Horikawa K, Nakashima K, Tokiwa H

出版信息

Mutat Res. 1983 Dec;124(3-4):201-11. doi: 10.1016/0165-1218(83)90191-x.

PMID:6197647

Abstract

The direct-acting mutagens in diesel particulate extracts were identified. It is concluded that the major mutagens are in all probability 1,6- and 1,8-dinitropyrene (DNP). 1-Nitropyrene (NP) and 3-nitrofluoranthene (NF) were also present. The DNP isomers contributed 43% of the total mutagenic activity of the crude extracts, whereas 1-NP (or 3-NF) was responsible for less than 10% of the activity. The quantities of 1,6- and 1,8-DNP were 1.2 and 3.4 ppm of the crude extracts, respectively, and the induction of both DNPs in the diesel particulate matter corresponded to about 1.7-4.8% by weight of the 1-NP content (70.5 ppm in the crude extracts).

摘要

已鉴定出柴油颗粒提取物中的直接作用诱变剂。得出的结论是，主要诱变剂很可能是1,6 - 二硝基芘和1,8 - 二硝基芘（DNP）。也存在1 - 硝基芘（NP）和3 - 硝基荧蒽（NF）。DNP异构体占粗提取物总诱变活性的43%，而1 - NP（或3 - NF）的活性占比不到10%。1,6 - DNP和1,8 - DNP的含量分别为粗提取物的1.2 ppm和3.4 ppm，柴油颗粒物中这两种DNP的含量约占1 - NP含量（粗提取物中为70.5 ppm）的1.7 - 4.8%（按重量计）。