Josiassen R C, Shagass C, Mancall E L, Roemer R A
Electroencephalogr Clin Neurophysiol. 1982 Nov;54(5):483-93. doi: 10.1016/0013-4694(82)90033-5.
Scalp recorded somatosensory evoked potentials (SEPs) elicited by left and right median nerve stimulation were obtained in 21 patients with Huntington's disease (HD), 14 individuals at risk (AR) for HD, and 21 non-patient controls matched for age and sex. Although SEP abnormalities were not uniform in the HD group, no HD patient had SEPs that conformed fully to the normal configuration with respect to peak latencies, presence of all components and spatial distribution. The most common abnormality was non-specific in nature, consisting of amplitude reduction or virtual abscence of components after 100 msec. More specific deviations were noted in the early SEP events. In half of the HD patients, peak P30 seemed to occur at approximately 45 msec poststimulus; this peak could have been taken as the normal P45 had it not reversed in phase between the central and frontal leads. In these cases peak P45 prepared to be missing. Peak N20 latency values were longer in the HD group than in the non-patient controls, whereas the P15 latencies did not differ significantly. The conduction time between P15 and N20 was significantly longer in HD patients than the non-patient controls. SEPs of the majority of the ARs were similar to those of the non-patients controls in terms of overall configuration, although mean amplitudes were generally lower for ARs than non-patient controls and 4 ARs exhibited prolonged P15-N20 latency differences.
对21例亨廷顿舞蹈病（HD）患者、14例有HD患病风险（AR）的个体以及21名年龄和性别匹配的非患者对照者，记录了由左右正中神经刺激诱发的头皮体感诱发电位（SEP）。尽管HD组的SEP异常并不一致，但没有HD患者的SEP在峰潜伏期、所有成分的存在以及空间分布方面完全符合正常形态。最常见的异常本质上是非特异性的，包括100毫秒后成分的波幅降低或几乎消失。在早期SEP事件中观察到了更具特异性的偏差。在一半的HD患者中，刺激后约45毫秒似乎出现了P30峰；如果该峰在中央和额部导联之间的相位没有反转，本可被视为正常的P45峰。在这些病例中，P45峰似乎缺失。HD组的N20峰潜伏期值比非患者对照者更长，而P15潜伏期没有显著差异。HD患者中P15和N20之间的传导时间比非患者对照者显著更长。大多数ARs的SEP在整体形态上与非患者对照者相似，尽管ARs的平均波幅通常低于非患者对照者，且4名ARs表现出P15 - N20潜伏期延长差异。
