维生素补充对老年人安替比林代谢的影响。
The effect of vitamin supplementation upon antipyrine metabolism in the elderly.
作者信息
Smithard D J, Langman M J
出版信息
Br J Clin Pharmacol. 1978 Feb;5(2):181-5. doi: 10.1111/j.1365-2125.1978.tb01621.x.
Abstract
1 Antipyrine plasma half-life and clearance rates were studied in 19 elderly patients shortly after admission to a geriatric ward and again 2 weeks after a course of dietary supplementation with Vitamins A, B complex, C and D. 2 Antipyrine half-life fell and clearance increased in the nine who had sub-clinical evidence of ascorbic acid deficiency. No correlation was found with other indices of nutritional status. 3 Vitamin supplementation in elderly people with no demonstrable deficiencies did not alter the metabolism of antipyrine.
摘要
- 对19名老年患者在入住老年病房后不久以及在接受维生素A、复合维生素B、维生素C和维生素D膳食补充疗程2周后，研究了安替比林的血浆半衰期和清除率。2. 在9名有亚临床维生素C缺乏证据的患者中，安替比林半衰期缩短，清除率增加。未发现与其他营养状况指标相关。3. 对无明显营养素缺乏的老年人补充维生素并未改变安替比林的代谢。
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本文引用的文献
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Ascorbic acid in aromatic hydroxylation. III. Effect of ascorbic acid on hydroxylation of acetanilide, aniline and antipyrine in vivo.抗坏血酸在芳环羟基化反应中的作用。III. 抗坏血酸对体内乙酰苯胺、苯胺和安替比林羟基化反应的影响。
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