[慢性多关节炎中的纤连蛋白及其他免疫学参数]
[Fibronectin and other immunologic parameters in chronic polyarthritis].
作者信息
Siegmeth W, Minar E, Graninger W, Pirich K, Zazgornik J
出版信息
Z Rheumatol. 1984 Jan-Feb;43(1):27-9.
In 20 patients with rheumatoid arthritis the plasma fibronectin concentrations were measured and correlated with the levels of C-reactive protein, alpha 1-antitrypsin, alpha 2-macroglobulin, fibrinogen, C3, C4 complement fractions and alpha 2-antiplasmin in serum respectively plasma. Patients with rheumatoid arthritis showed plasma fibronectin concentrations within reference levels. However, the concentrations of C-reactive protein, alpha 1-antitrypsin, alpha 2-antiplasmin, fibrinogen and C3-complement fraction were significantly higher in comparison to the healthy controls. The results indicate that fibronectin does not belong to the group of "acute phase proteins". Measurement of plasma fibronectin give no additional information about the activity of rheumatoid arthritis.
对20例类风湿性关节炎患者的血浆纤连蛋白浓度进行了测定，并分别与血清中的C反应蛋白、α1抗胰蛋白酶、α2巨球蛋白、纤维蛋白原、C3、C4补体成分以及血浆中的α2抗纤溶酶水平进行了相关性分析。类风湿性关节炎患者的血浆纤连蛋白浓度在参考水平范围内。然而，与健康对照组相比，C反应蛋白、α1抗胰蛋白酶、α2抗纤溶酶、纤维蛋白原和C3补体成分的浓度显著更高。结果表明，纤连蛋白不属于“急性期蛋白”组。血浆纤连蛋白的测定并未提供有关类风湿性关节炎活动的额外信息。
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