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神经肽Y：在人类尸检大脑中的区域分布、色谱特征及免疫组化显示

Neuropeptide Y: regional distribution chromatographic characterization and immunohistochemical demonstration in post-mortem human brain.

作者信息

Dawbarn D, Hunt S P, Emson P C

出版信息

Brain Res. 1984 Mar 26;296(1):168-73. doi: 10.1016/0006-8993(84)90526-2.

DOI:10.1016/0006-8993(84)90526-2
PMID:6201235
Abstract

Using a neuropeptide Y (NPY)-directed radioimmunoassay the post-mortem stability of NPY was assessed in both rat and human brain samples. The regional distribution of NPY-like immunoreactivity in human brain was determined. The NPY-like immunoreactivity in human brain separated on Sephadex G-50 columns and 18C reverse phase at the position expected for NPY. Immunohistochemical staining using the NPY-directed antiserum revealed a characteristic population of cortical and striatal neurons containing NPY-like immunoreactivity.

摘要

使用一种针对神经肽Y（NPY）的放射免疫分析法，在大鼠和人类脑样本中评估了NPY的死后稳定性。确定了人类脑中NPY样免疫反应性的区域分布。人类脑中的NPY样免疫反应性在Sephadex G - 50柱和18C反相上，在NPY预期的位置被分离出来。使用针对NPY的抗血清进行免疫组织化学染色，揭示了一群含有NPY样免疫反应性的皮质和纹状体神经元的特征。

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Neuropeptide Y: regional distribution chromatographic characterization and immunohistochemical demonstration in post-mortem human brain.神经肽Y：在人类尸检大脑中的区域分布、色谱特征及免疫组化显示
Brain Res. 1984 Mar 26;296(1):168-73. doi: 10.1016/0006-8993(84)90526-2.
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