Borgström A, Wehlin L
Scand J Gastroenterol. 1984 Mar;19(2):220-7.
The concentrations of pancreatic amylase, immunoreactive trypsin, and immunoreactive pancreatic specific trypsin inhibitor have been studied in serum drawn from 258 patients before an endoscopic retrograde cholangiopancreatography (ERCP) examination, in which both ducts were successfully filled. The results are correlated to the morphology of the ducts and the diagnosis given at the ERCP examination. One third of the patients with normal morphology of both ducts showed an abnormal concentration of at least one of the measured specific pancreatic proteins. Sixteen out of 38 patients with changes suggestive of chronic pancreatitis and 6 out of 23 patients with changes suggestive of pancreatic cancer showed normal levels of all variables measured. The sensitivity and specificity for pancreatic disease evident by ERCP were around 0.40 and 0.80, respectively, for all three proteins.
对258例患者在进行内镜逆行胰胆管造影（ERCP）检查前抽取的血清中胰淀粉酶、免疫反应性胰蛋白酶和免疫反应性胰腺特异性胰蛋白酶抑制剂的浓度进行了研究，在该检查中两个导管均成功显影。结果与导管形态以及ERCP检查给出的诊断相关。两个导管形态正常的患者中有三分之一显示至少一种所测胰腺特异性蛋白浓度异常。38例有提示慢性胰腺炎改变的患者中有16例，23例有提示胰腺癌改变的患者中有6例，所测所有变量水平均正常。对于所有三种蛋白质，ERCP显示的胰腺疾病的敏感性和特异性分别约为0.40和0.80。
