Glen J B, Hunter S C
Br J Anaesth. 1984 Jun;56(6):617-26. doi: 10.1093/bja/56.6.617.
Studies with an emulsion formulation of ICI 35 868 (2,6- diisopropylphenol ) indicate that this new formulation has anaesthetic properties in rats and mice, and haemodynamic effects in the mini-pig which are similar to those of the previously available Cremophor formulation. Administration of the emulsion formulation to dogs produced no untoward effect, whereas the Cremophor formulation produced a marked increase in plasma histamine concentration. In the mini-pig, no adverse response was produced by the repeated administration of the emulsion formulation of ICI 35 868, whereas the Cremophor formulation produced anaphylactoid responses when a second injection was given 1 week after an uneventful first exposure to this formulation. Behavioural responses in the rat suggest that the emulsion formulation may produce less discomfort on i.v. injection.
对ICI 35868（2,6 - 二异丙基苯酚）乳剂配方的研究表明，这种新配方在大鼠和小鼠中具有麻醉特性，在小型猪中具有血流动力学效应，这些效应与先前可用的聚氧乙烯蓖麻油配方相似。给狗施用乳剂配方未产生不良影响，而聚氧乙烯蓖麻油配方导致血浆组胺浓度显著升高。在小型猪中，重复施用ICI 35868乳剂配方未产生不良反应，而聚氧乙烯蓖麻油配方在首次平稳接触该配方1周后进行第二次注射时产生类过敏反应。大鼠的行为反应表明，乳剂配方静脉注射时可能产生较少不适。
