Hynynen M, Korttila K, Tammisto T
Acta Anaesthesiol Scand. 1985 Aug;29(6):651-2. doi: 10.1111/j.1399-6576.1985.tb02274.x.
Pain on injection of three anaesthetic induction agents, thiopentone, methohexitone and propofol (diisopropyl phenol), administered into a vein on the dorsum of the hand or wrist, was studied in 32 premedicated patients undergoing elective surgery. The pain was rated as none, mild or severe. A 1% emulsion formulation of propofol (ICI 35 868) (2 mg kg-1) and methohexitone (2 mg kg-1) induced pain significantly more often, in 100% and 80% of patients, respectively, than thiopentone (4 mg kg-1), 0%. The pain was rated as severe more often in patients receiving propofol (67%, P less than 0.01 vs thiopentone) than in those anaesthetized with methohexitone (20%) or thiopentone (0%). It is concluded that the fat emulsion form of propofol, when injected into a peripheral vein, frequently induces severe pain.
在32例接受择期手术且已进行术前用药的患者中，研究了将三种麻醉诱导剂（硫喷妥钠、美索比妥和丙泊酚（二异丙基苯酚））注入手背或手腕静脉时的疼痛情况。疼痛程度分为无、轻度或重度。丙泊酚（ICI 35 868）的1%乳剂配方（2毫克/千克）和美索比妥（2毫克/千克）引起疼痛的频率明显高于硫喷妥钠（4毫克/千克），分别为100%和80%的患者出现疼痛，而硫喷妥钠组为0%。接受丙泊酚的患者中疼痛被评为重度的频率更高（67%，与硫喷妥钠相比P<0.01），高于接受美索比妥麻醉的患者（20%）或硫喷妥钠麻醉的患者（0%）。结论是，丙泊酚的脂肪乳剂形式注入外周静脉时，经常会引起剧烈疼痛。
