Kuo T T, Hsueh S
Am J Surg Pathol. 1984 Jun;8(6):419-28. doi: 10.1097/00000478-198406000-00002.
In Taiwan, a peculiar type of cell with mucicarmine-positive bubbly or vacuolated cytoplasm was sporadically observed in a variety of surgical specimens removed for neoplastic or non-neoplastic conditions. They closely mimicked signet-ring cell carcinoma. Study of 14 such cases and review of the related literature led to the conclusion that the peculiar cells were storage histiocytes containing polyvinylpyrrolidone (PVP). Because they were shown to be mucicarmine-positive, we designated them " mucicarminophilic histiocytes." Particulate bodies sometimes observed in association with mucicarminophilic histiocytes were believed to be the extracellular counterpart of the cytoplasmic vacuoles. Our survey also revealed that PVP-containing intravenous injection fluids had been used in Taiwan as recently as 5 years ago. For surgical pathologists, PVP-containing mucicarminophilic histiocytes should not be mistaken for signet-ring cell carcinoma or signet-ring cell lymphoma. Mucicarminophilic histiocytes can be identified by the positive mucicarmine, colloidal iron, Gomori methenamine silver, Congo red, Sudan black B, Fontana-Masson argentaffin, and Victoria blue; but negative periodic acid-Schiff, alcian blue, and Giemsa stains.
在台湾，在因肿瘤性或非肿瘤性疾病而切除的各种手术标本中偶尔观察到一种特殊类型的细胞，其胞质经黏液卡红染色呈阳性，呈泡沫状或空泡状。它们与印戒细胞癌极为相似。对14例此类病例的研究及相关文献回顾得出结论，这种特殊细胞是含有聚乙烯吡咯烷酮（PVP）的贮积性组织细胞。由于它们经黏液卡红染色呈阳性，我们将其命名为“嗜黏液卡红组织细胞”。有时与嗜黏液卡红组织细胞相关联观察到的颗粒体被认为是胞质空泡的细胞外对应物。我们的调查还显示，就在5年前台湾还在使用含PVP的静脉注射液。对于外科病理学家而言，含PVP的嗜黏液卡红组织细胞不应被误诊为印戒细胞癌或印戒细胞淋巴瘤。嗜黏液卡红组织细胞可通过黏液卡红、胶态铁、Gomori六胺银、刚果红、苏丹黑B、Fontana-Masson嗜银染色及维多利亚蓝染色呈阳性来鉴别；但过碘酸-希夫、阿尔辛蓝及吉姆萨染色呈阴性。
