Nakano K, Suzuki S
J Nutr. 1984 Sep;114(9):1602-8. doi: 10.1093/jn/114.9.1602.
Effects of acute immobilization stress on the metabolism of ascorbic acid and histamine were studied in rats by determining changes in the tissue levels of these substances. Stress provoked a significant rise in the histamine levels of blood, stomach, kidney, lung and skin. The serum ascorbic acid level increased rapidly, whereas the amount of the vitamin in the lung and skin was reduced by stress. The hepatic ascorbic acid levels were modulated biphasically; there was a decrease within 15 minutes after the onset of the stress regimen, followed by an increase occurring during the next 15 minutes. There was a gradual decrease in the amount of ascorbic acid in the adrenal glands with a marked transient accumulation of corticosterone in the tissues. Administration of histamine caused an increase in the serum level of ascorbic acid, while it led to a transitory decrease in the hepatic level of the vitamin. These results suggest that the metabolism of ascorbic acid is modulated in rats suffering from stress. These changes in ascorbic acid metabolism seem to be closely associated with the stress-induced alteration of histamine metabolism.
通过测定大鼠体内这些物质的组织水平变化，研究了急性固定应激对其抗坏血酸和组胺代谢的影响。应激导致血液、胃、肾、肺和皮肤中的组胺水平显著升高。血清抗坏血酸水平迅速增加，而应激使肺和皮肤中的维生素量减少。肝脏抗坏血酸水平呈双相调节；应激方案开始后15分钟内降低，随后在接下来的15分钟内升高。肾上腺中抗坏血酸的量逐渐减少，同时组织中皮质酮有明显的短暂积累。给予组胺会导致血清抗坏血酸水平升高，同时导致肝脏中该维生素水平短暂降低。这些结果表明，应激大鼠的抗坏血酸代谢受到调节。抗坏血酸代谢的这些变化似乎与应激诱导的组胺代谢改变密切相关。
