Coleman D, Falkiner F R, Carr M E, Dowd G, Dougan G, Keane C T
J Hosp Infect. 1984 Sep;5(3):270-82. doi: 10.1016/0195-6701(84)90076-8.
Seventy isolates of Serratia marcescens were obtained from 30 patients in different units of one hospital between April 1982 and February 1983. No common source was found. Not all isolates were multi-resistant and nearly all that were, fell into two main groups, A and B. These groups were defined by phage typing and cephalosporin sensitivity, all apart from one Group B isolate were multi-resistant, whereas Group A isolates contained multi-resistant and sensitive strains. Plasmid screening, resistance transfer studies and plasmid elimination experiments demonstrated that the multi-resistant phenotype was due to a 120 Mdal transmissible plasmid. Resistance to cephalosporins was chromosomally encoded.
1982年4月至1983年2月期间，从一家医院不同科室的30名患者中分离出70株粘质沙雷氏菌。未发现共同来源。并非所有分离株都具有多重耐药性，几乎所有具有多重耐药性的分离株都分为A和B两个主要组。这些组通过噬菌体分型和头孢菌素敏感性来定义，除了一株B组分离株外，所有分离株都具有多重耐药性，而A组分离株包含多重耐药和敏感菌株。质粒筛选、耐药性转移研究和质粒消除实验表明，多重耐药表型是由一个120 Mdal的可传递质粒引起的。对头孢菌素的耐药性是由染色体编码的。
