Farmer J J, Davis B R, Hickman F W, Presley D B, Bodey G P, Negut M, Bobo R A
Lancet. 1976 Aug 28;2(7983):455-9. doi: 10.1016/s0140-6736(76)92539-3.
Infections due to Serratia marcescens were studied in 23 different hospitals. A retrospective study was done in 4 hospitals; all isolates were compared by serological typing, antibiograms, bacteriocin production, and bacteriocin sensitivity. 2 of the hospitals were having cross-infection problems due to antibiotic-resistant strains, but the other 2 had little or no cross-infection. Outbreaks were studied in 19 other hospitals. 9 of these outbreaks were classified as "common source" since contaminated "sterile solutions" were incriminated as the cause in each. One hospital had a "pseudo-outbreak," in which Serratia from E.D.T.A. blood-collecting tubes contaminated blood-cultures as they were collected. All 10 of these strains from common-source outbreaks were generally sensitive to antibiotics. Outbreaks in 9 other hospitals resulted from cross-infection and were caused by strains which were very resistant to antibiotics. Guidelines for detecting outbreaks are given and control measures are suggested.
对23家不同医院里由粘质沙雷氏菌引起的感染进行了研究。在4家医院进行了回顾性研究；通过血清学分型、抗菌谱、细菌素产生及细菌素敏感性对所有分离株进行了比较。其中2家医院存在因耐药菌株导致的交叉感染问题，但另外2家医院几乎没有交叉感染情况。在另外19家医院对疫情爆发情况进行了研究。其中9起疫情爆发被归类为“共同来源”，因为每次都认定受污染的“无菌溶液”是病因。一家医院出现了“假性疫情爆发”，即来自乙二胺四乙酸（EDTA）采血试管的粘质沙雷氏菌在采集血培养样本时将其污染。这些共同来源疫情爆发中的所有10株菌株通常对抗生素敏感。其他9家医院的疫情爆发是由交叉感染引起的，且是由对抗生素高度耐药的菌株所致。文中给出了检测疫情爆发的指导原则并提出了控制措施。
