羟羧氧酰胺菌素（LY127935）治疗革兰氏阴性杆菌所致脑膜炎
Moxalactam (LY127935) in treatment of meningitis due to gram-negative bacilli.
作者信息
Fisher J F, Carter M J, Parsons J, Rissing J P
出版信息
Antimicrob Agents Chemother. 1981 Feb;19(2):218-21. doi: 10.1128/AAC.19.2.218.
Abstract
Moxalactam (LY127935; 6059S), a new broad-spectrum beta-lactam antibiotic, was used successfully with an aminoglycoside in a patient with Serratia marcescens meningitis complicating a neurosurgical procedure. With a bioassay method, peak and trough serum and cerebrospinal; fluid concentrations of moxalactam were determined during therapy. Mean peak and trough serum levels were 100.6 and 35.5 micrograms/ml, respectively. Corresponding mean peak and trough cerebrospinal fluid levels were 12.4 and 10.38 micrograms/ml. Cerebrospinal fluid levels of moxalactam exceeded the minimal bactericidal concentration for the infecting organism by more than 30-fold throughout therapy. No untoward effects of moxalactam were observed. Moxalactam may be a useful agent in the treatment of meningitis due to susceptible gram-negative bacilli.
摘要
莫西拉酸（LY127935；6059S），一种新型广谱β-内酰胺抗生素，在一名因神经外科手术并发粘质沙雷氏菌脑膜炎的患者中与一种氨基糖苷类药物联合使用成功。采用生物测定法，在治疗期间测定了莫西拉酸的血清和脑脊液峰浓度及谷浓度。血清平均峰浓度和谷浓度分别为100.6微克/毫升和35.5微克/毫升。相应的脑脊液平均峰浓度和谷浓度分别为12.4微克/毫升和10.38微克/毫升。在整个治疗过程中，莫西拉酸的脑脊液浓度超过感染病原体的最低杀菌浓度30多倍。未观察到莫西拉酸的不良反应。莫西拉酸可能是治疗由敏感革兰氏阴性杆菌引起的脑膜炎的有用药物。
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