Naganuma A, Tabata J, Imura N
Res Commun Chem Pathol Pharmacol. 1982 Nov;38(2):291-9.
Reaction of mercuric mercury and selenite in the presence of reduced glutathione (GSH) was studied. A black complex containing GSH and equimolar amounts of mercury and selenium was obtained by the reaction of sodium selenite and mercuric chloride in the presence of excess amounts of GSH. This complex was soluble in water, but insoluble in ethanol. Toxicity of the complex was very low in comparison with mercuric chloride or sodium selenite. Formation of such complex of lower toxicity in animals as described above may play an important role in the modification of toxicity of mercuric mercury by selenite.
研究了在还原型谷胱甘肽（GSH）存在下汞离子与亚硒酸盐的反应。通过在过量GSH存在下亚硒酸钠与氯化汞反应，得到了一种含有GSH以及等摩尔量汞和硒的黑色络合物。该络合物可溶于水，但不溶于乙醇。与氯化汞或亚硒酸钠相比，该络合物的毒性非常低。上述动物体内形成这种低毒性络合物可能在亚硒酸盐对汞离子毒性的修饰中起重要作用。
