同时给药后家兔组织可溶性部分中汞和硒分布的变化。
Changes in distribution of mercury and selenium in soluble fractions of rabbit tissues after simultaneous administration.
作者信息
Naganuma A, Imura N
出版信息
Pharmacol Biochem Behav. 1980 Oct;13(4):537-44. doi: 10.1016/0091-3057(80)90277-4.
The existing states of mercury and selenium in the blood and in soluble fractions of perfused rabbit liver and kidney were studied by gel filtration on Sephadex G-200 1 hr or 24 hr after intravenous injection of mercuric chloride and/or sodium selenite. Both mercury and selenium in the plasma and stroma-free hemolysate were found to exist in the high-molecular weight fraction following simultaneous injection of mercuric chloride and sodium selenite. Patterns in gel filtration of the plasma and the stroma-free hemolysate did not show any significant change between 1 hr and 24 hr after the administration. A similar tendency as described above was obtained with the liver-soluble fraction at 24 hr after injection of mercuric chloride and sodium selenite. A possible role of the high-molecular weight complex, which is quickly formed by the interaction of mercury and selenium in blood stream, in decreasing the acute renal toxicity of inorganic mercury is discussed.
静脉注射氯化汞和/或亚硒酸钠1小时或24小时后，通过在Sephadex G - 200上进行凝胶过滤，研究了家兔血液以及灌注肝脏和肾脏的可溶部分中汞和硒的存在状态。同时注射氯化汞和亚硒酸钠后，血浆和无基质溶血产物中的汞和硒均存在于高分子量部分。给药后1小时至24小时之间，血浆和无基质溶血产物的凝胶过滤模式未显示任何显著变化。注射氯化汞和亚硒酸钠24小时后，肝脏可溶部分也得到了上述类似趋势。讨论了在血流中汞和硒相互作用迅速形成的高分子量复合物在降低无机汞急性肾毒性方面可能发挥的作用。
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