Magos L, Clarkson T W, Hudson A R
J Pharmacol Exp Ther. 1984 Feb;228(2):478-83.
The interaction was compared between inorganic (HgCl2) mercury and selenite (Na2SeO3) vs. the interaction between inorganic mercury and biological selenium (a freeze-dried preparation of liver from rats treated with selenite). Organ concentrations of selenium were always significantly lower after biological selenium than after selenite. Biological selenium affected the organ distribution of inorganic mercury differently than selenite. Furthermore, the speciation of mercury was affected by this form of selenium. A mercury-selenide compound (presumably HgSe) accounted for a greater proportion of total mercury in tissues after selenite than after a dose of biological selenium. Administration of selenomethionine had a similar effect on the speciation of mercury to that seen after biological selenium. As the forms of selenium in selenomethionine or selenium deposited in the liver are most likely nearer than selenite to selenium present in food, our results suggest that, as far as the reaction of mercury with selenide is concerned, experiments with selenite overestimate the protective effect of dietary selenium against inorganic mercury and possibly against methylmercury.
对无机汞（HgCl₂）与亚硒酸盐（Na₂SeO₃）之间的相互作用，以及无机汞与生物硒（用亚硒酸盐处理过的大鼠肝脏冻干制剂）之间的相互作用进行了比较。生物硒处理后，各器官中的硒浓度始终显著低于亚硒酸盐处理后的浓度。生物硒对无机汞在器官中的分布影响与亚硒酸盐不同。此外，汞的形态受这种形式的硒的影响。与给予生物硒剂量后相比，亚硒酸盐处理后，一种硒化汞化合物（可能是HgSe）在组织总汞中所占比例更大。给予硒代蛋氨酸对汞形态的影响与生物硒处理后相似。由于硒代蛋氨酸中的硒形式或肝脏中沉积的硒比亚硒酸盐更接近食物中存在的硒，我们的结果表明，就汞与硒化物的反应而言，用亚硒酸盐进行的实验高估了膳食硒对无机汞以及可能对甲基汞的保护作用。
