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1
Characterization of the killer cell generated in the autologous mixed leukocyte reaction.自体混合淋巴细胞反应中产生的杀伤细胞的特性分析。
J Exp Med. 1983 Apr 1;157(4):1309-23. doi: 10.1084/jem.157.4.1309.
2
Characterization of the natural killer-like lymphocytes in rheumatoid synovial fluid.类风湿性滑液中自然杀伤样淋巴细胞的特征分析
J Immunol. 1985 Mar;134(3):1483-6.
3
Characterization of the precursors of the NK-like cytotoxic cells generated in the autologous mixed leukocyte reaction and by interleukin 2 activation.对自体混合淋巴细胞反应及白细胞介素2激活产生的自然杀伤样细胞毒性细胞前体的特性分析。
J Clin Lab Immunol. 1986 Mar;19(3):105-11.
4
Depletion of human NK cells with monoclonal antibodies allows the generation of cytotoxic T lymphocytes without NK-like cells in mixed cultures.用单克隆抗体耗尽人自然杀伤细胞可使混合培养物中产生无自然杀伤样细胞的细胞毒性T淋巴细胞。
J Immunol. 1983 Apr;130(4):1556-60.
5
Fucose-activated killer (FAK) cells: anomalous killers with augmented cytotoxic activity.岩藻糖激活杀伤细胞（FAK细胞）：具有增强细胞毒性活性的异常杀伤细胞。
J Immunol. 1985 Dec;135(6):3719-28.
6
Regulation of cytolytic activity in CD3- and CD3+ killer cell clones by monoclonal antibodies (anti-CD16, anti-CD2, anti-CD3) depends on subclass specificity of target cell IgG-FcR.单克隆抗体（抗CD16、抗CD2、抗CD3）对CD3 - 和CD3 + 杀伤细胞克隆的细胞溶解活性的调节取决于靶细胞IgG - FcR的亚类特异性。
J Immunol. 1987 May 15;138(10):3137-44.
7
In vitro generation of human activated lymphocyte killer cells: separate precursors and modes of generation of NK-like cells and "anomalous" killer cells.人活化淋巴细胞杀伤细胞的体外生成：自然杀伤样细胞和“异常”杀伤细胞的不同前体及生成模式。
J Immunol. 1984 Sep;133(3):1656-63.
8
Cytotoxic T cells generated in the autologous mixed lymphocyte reaction. I. Primary autologous mixed lymphocyte reaction.自体混合淋巴细胞反应中产生的细胞毒性T细胞。I. 原发性自体混合淋巴细胞反应。
J Immunol. 1980 Mar;124(3):1111-21.
9
A novel functional cell surface dimer (Kp43) expressed by natural killer cells and gamma/delta TCR+ T lymphocytes. II. Modulation of natural killer cytotoxicity by anti-Kp43 monoclonal antibody.一种由自然杀伤细胞和γ/δTCR+T淋巴细胞表达的新型功能性细胞表面二聚体（Kp43）。II. 抗Kp43单克隆抗体对自然杀伤细胞细胞毒性的调节。
J Immunol. 1991 Jul 15;147(2):714-21.
10
Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity.与自体黑色素瘤细胞反应的克隆化人细胞毒性T淋巴细胞（CTL）系。I. 体外生成、分离及表型和特异性分析。
J Immunol. 1984 Jan;132(1):510-9.

引用本文的文献

1
Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens.通过Leu-11和II类组织相容性抗原的表达鉴定在人混合淋巴细胞反应培养物中活化的自然杀伤细胞。
J Exp Med. 1984 Apr 1;159(4):993-1008. doi: 10.1084/jem.159.4.993.
2
Characterization of IL-2 responsive synovial T lymphocytes in rheumatoid arthritis. II. Functional properties.类风湿关节炎中白细胞介素-2反应性滑膜T淋巴细胞的特征。II. 功能特性。
Rheumatol Int. 1987;7(4):147-51. doi: 10.1007/BF00270362.
3
Lymphokine-activated killer cell activity in rheumatoid arthritis.类风湿关节炎中的淋巴因子激活的杀伤细胞活性
Clin Exp Immunol. 1987 Jun;68(3):535-42.
4
Natural killer (NK) cells at inflammatory sites of patients with rheumatoid arthritis and IgM rheumatoid factor positive polyarticular juvenile rheumatoid arthritis.类风湿关节炎患者及IgM类风湿因子阳性多关节型幼年特发性关节炎患者炎症部位的自然杀伤（NK）细胞
Clin Rheumatol. 1987 Jun;6(2):215-25. doi: 10.1007/BF02201027.
5
Cloned human cytotoxic T lymphocytes develop anomalous killer cell function.克隆化的人细胞毒性T淋巴细胞产生异常的杀伤细胞功能。
Clin Exp Immunol. 1986 Dec;66(3):558-65.
6
Phenotypes and spontaneous cell cytotoxicity of mononuclear cells from patients with seronegative spondyloarthropathies: ankylosing spondylitis, psoriatic arthropathy and pauciarticular juvenile chronic arthritis--analysis of mononuclear cells from peripheral blood, synovial fluid and synovial membranes.血清阴性脊柱关节病患者单核细胞的表型及自发细胞毒性：强直性脊柱炎、银屑病关节炎和少关节型幼年慢性关节炎——外周血、滑液和滑膜的单核细胞分析
Clin Rheumatol. 1988 Mar;7(1):95-106. doi: 10.1007/BF02284064.
7
Regulation of human natural killer (NK) cell function: induction of killing of an NK-resistant renal carcinoma cell line.人类自然杀伤（NK）细胞功能的调节：诱导对NK有抗性的肾癌细胞系的杀伤作用。
J Clin Immunol. 1988 Jan;8(1):69-79. doi: 10.1007/BF00915159.
8
A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562.一种人类自然杀伤细胞分化模型。用自然杀伤敏感肿瘤细胞K562对Leu-11 +颗粒淋巴细胞进行体外激活的研究。
J Exp Med. 1985 Jun 1;161(6):1464-82. doi: 10.1084/jem.161.6.1464.
9
New perspectives on the pathogenesis of rheumatoid arthritis.类风湿关节炎发病机制的新观点。
Am J Med. 1988 Oct 14;85(4A):12-7. doi: 10.1016/0002-9343(88)90356-7.
10
Spontaneous production of an interleukin 1-like factor by cloned rheumatoid synovial cells in long-term culture.长期培养的类风湿性滑膜细胞自发产生白细胞介素1样因子。
J Clin Invest. 1987 Sep;80(3):786-96. doi: 10.1172/JCI113135.

本文引用的文献

1
Phenotypes of human natural killer cell populations detected with monoclonal antibodies.用单克隆抗体检测的人类自然杀伤细胞群体的表型
J Immunol. 1981 Dec;127(6):2575-80.
2
Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes.一种与人类单核细胞及一部分活化淋巴细胞结合的单克隆抗体（4F2）的特性
J Immunol. 1981 Apr;126(4):1409-14.
3
Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody.通过单克隆HNK-1抗体鉴定的人类自然杀伤细胞和杀伤细胞群体的产后扩增。
J Exp Med. 1982 Jan 1;155(1):321-6. doi: 10.1084/jem.155.1.321.
4
Macrophage heterogeneity in man. A subpopulation of HLA-DR-bearing macrophages required for antigen-induced T cell activation also contains stimulators for autologous-reactive T cells.人类巨噬细胞的异质性。抗原诱导的T细胞活化所需的携带HLA - DR的巨噬细胞亚群也包含自身反应性T细胞的刺激物。
J Exp Med. 1980 Sep 1;152(3):581-93. doi: 10.1084/jem.152.3.581.
5
Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.由单克隆抗体定义的人类T细胞抗原：T细胞的65000道尔顿抗原（T65）也存在于带有表面免疫球蛋白的慢性淋巴细胞白血病细胞上。
J Immunol. 1980 Aug;125(2):725-31.
6
The differentiation and function of human T lymphocytes.人类T淋巴细胞的分化与功能。
Cell. 1980 Apr;19(4):821-7. doi: 10.1016/0092-8674(80)90072-0.
7
A monoclonal antibody reactive with human peripheral blood monocytes.一种与人外周血单核细胞反应的单克隆抗体。
J Immunol. 1980 Apr;124(4):1943-8.
8
Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies.单克隆OKT3和Leu-2a抗体在靶细胞识别或裂解起始水平对人T细胞细胞毒性的选择性抑制。
J Exp Med. 1982 May 1;155(5):1579-84. doi: 10.1084/jem.155.5.1579.
9
Inhibition of specific cell-mediated cytotoxicity by monoclonal antibodies to human T cell antigens.抗人T细胞抗原单克隆抗体对特异性细胞介导细胞毒性的抑制作用。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4500-4. doi: 10.1073/pnas.78.7.4500.
10
Distribution of t lymphocyte subsets in the human bone marrow and thymus: an analysis with monoclonal antibodies.人类骨髓和胸腺中T淋巴细胞亚群的分布：单克隆抗体分析
J Immunol. 1981 Apr;126(4):1608-13.

自体混合淋巴细胞反应中产生的杀伤细胞的特性分析。

Characterization of the killer cell generated in the autologous mixed leukocyte reaction.

作者信息

Goto M, Zvaifler N J

出版信息

J Exp Med. 1983 Apr 1;157(4):1309-23. doi: 10.1084/jem.157.4.1309.

DOI:10.1084/jem.157.4.1309
PMID:6220110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186976/
Abstract

Cytotoxic cells are produced in an autologous mixed leukocyte reaction (AMLR). At 1 wk in culture the AMLR killers are mainly IgG Fc- cells and can kill autologous lymphoblastoid cell lines and Raji and Daudi targets that are usually resistant to natural killer cell (NK) lysis. To define the phenotype of these cells, we have used complement (C')-mediated lysis with monoclonal antibodies (MAb). AMLR killer activity was virtually eliminated by treatment with C' and 9.6 or 4F2, but the cytotoxic cells did not express NK-specific antigens, OKM1 and Leu-7, nor cytolytic T lymphocyte-specific antigens, 9.3 and OKT8. None of the 10 MAb used could significantly block cytotoxicity at the final concentration of 1.5 mcg/ml which is generally sufficient to inhibit CTL. The majority of cells at 1 wk in AMLR cultures stained with T cell activation antigens Ia and 4F2; AMLR killing was proportional to the percentage of 4F2+ cells but unrelated to the expression of Ia antigen.

摘要

细胞毒性细胞在自体混合淋巴细胞反应（AMLR）中产生。培养1周时，AMLR杀伤细胞主要是IgG Fc - 细胞，可杀伤自体淋巴母细胞系以及通常对自然杀伤细胞（NK）裂解有抗性的Raji和Daudi靶细胞。为了确定这些细胞的表型，我们使用了单克隆抗体（MAb）介导的补体（C'）介导的裂解。用C'和9.6或4F2处理几乎消除了AMLR杀伤活性，但细胞毒性细胞不表达NK特异性抗原OKM1和Leu - 7，也不表达细胞溶解性T淋巴细胞特异性抗原9.3和OKT8。在1.5 mcg/ml的终浓度下，所使用的10种MAb中没有一种能显著阻断细胞毒性，该浓度通常足以抑制细胞毒性T淋巴细胞（CTL）。AMLR培养1周时的大多数细胞用T细胞活化抗原Ia和4F2染色；AMLR杀伤与4F2 + 细胞的百分比成正比，但与Ia抗原的表达无关。