Robinson A E, Penny A F, Smith J, Tovey D L
Vox Sang. 1983 Mar;44(3):143-50. doi: 10.1111/j.1423-0410.1983.tb01876.x.
A pilot study for large-scale automated plasmapheresis using the Haemonetics Model 50 machine was undertaken in the Yorkshire Region of the United Kingdom to determine the viability of such a programme for national self-sufficiency in fresh plasma procurement for factor VIII concentrate production. The study was designed to resolve three areas of concern: donor safety and recruitment; a cost analysis, and the choice of anticoagulant for optimum factor VIII yields. The results show that large-scale automated plasmapheresis could safely and economically produce high-quality source plasma necessary for national self-sufficiency.
在英国约克郡地区开展了一项使用Haemonetics Model 50机器进行大规模自动化血浆置换的试点研究，以确定这样一个项目对于国家在生产凝血因子VIII浓缩物时实现新鲜血浆采购自给自足的可行性。该研究旨在解决三个令人关注的领域：供体安全与招募；成本分析，以及为实现最佳凝血因子VIII产量而选择抗凝剂。结果表明，大规模自动化血浆置换能够安全且经济地生产出国家自给自足所需的高质量原料血浆。
