Hu S K, Eardley D D, Cantor H, Gershon R K
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3779-81. doi: 10.1073/pnas.80.12.3779.
Antigen-stimulated Ly1 cells induce T cells from nonimmune donors to develop potent feedback suppressive activity. Suppression is mediated by Ly23 suppressor T (Ts) cells, which are generated from either Ly23 or Ly123 precursors. Ts activity generated from Ly23 precursors requires a strong inducer signal and is rapidly expressed but short lived. In contrast, Ts activity from Ly123 precursors is relatively long lived and is efficiently generated by relatively low levels of inducer signals. Induction of both Ly123 and Ly23 precursors to become Ts cells requires that both cells share genes linked to the Ig-H locus.
抗原刺激的Ly1细胞可诱导非免疫供体的T细胞产生强大的反馈抑制活性。抑制作用由Ly23抑制性T（Ts）细胞介导，这些细胞由Ly23或Ly123前体细胞产生。由Ly23前体细胞产生的Ts活性需要强烈的诱导信号，且表达迅速但持续时间短。相比之下，来自Ly123前体细胞的Ts活性持续时间相对较长，并且在相对较低水平的诱导信号下就能有效产生。将Ly123和Ly23前体细胞诱导成为Ts细胞都需要这两种细胞共享与Ig-H基因座相关的基因。
