静脉注射脉冲式甲基强的松龙对强直性脊柱炎免疫和炎症过程的影响。
The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.
作者信息
Richter M B, Woo P, Panayi G S, Trull A, Unger A, Shepherd P
出版信息
Clin Exp Immunol. 1983 Jul;53(1):51-9.
Abstract
Acute phase reactants, serum immunoglobulins and immune complexes and T cell function were measured in eight patients with active ankylosing spondylitis (AS) before and up to 3 months after three pulses of 1 g methylprednisolone. There was a two stage effect. The first stage was an early anti-inflammatory event with a fall in clinical disease activity mirrored by changes in acute phase reactants particularly prealbumin. The second stage occurred later and was an immunological event with a fall in serum IgA and IgG and a rise in mitogenic response, mixed lymphocyte response and delayed cutaneous hypersensitivity. Most of these changes returned towards pre-treatment levels by 3 months. This study has shown that pulse methylprednisolone has an immediate anti-inflammatory and a prolonged immunological effect in AS.
摘要
对8例活动期强直性脊柱炎（AS）患者在给予3次1g甲泼尼龙冲击治疗前及治疗后长达3个月的时间内，检测了急性期反应物、血清免疫球蛋白、免疫复合物及T细胞功能。结果显示有两阶段效应。第一阶段为早期抗炎事件，临床疾病活动度下降，急性期反应物尤其是前白蛋白的变化反映了这一点。第二阶段出现较晚，是一个免疫事件，血清IgA和IgG下降，有丝分裂原反应、混合淋巴细胞反应及迟发性皮肤超敏反应增强。到3个月时，这些变化大多恢复到治疗前水平。本研究表明，冲击甲泼尼龙在强直性脊柱炎中具有即刻抗炎及持久的免疫效应。
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