Wagner A, Plewig G
MMW Munch Med Wochenschr. 1980 Sep 19;122(38):1294-300.
This study shows that severe acne is characterized by numerous inflammatory parameters. The group of acne tetrad patients differed from those with conglobate acne in many laboratory measurements. The treatment with 13-cis-retinoic acid was well tolerated by all patients. Sebum suppression and an exfoliative cheilitis occurred in all patients, but no headache and no loss hair. Numerous previously pathological blood chemical values were normalized during the treatment. Transaminases, alkaline phosphatase, triglycerides and total cholesterol did not rise noticeably, trichological and spermatological parameters were not affected by 13-cis-retinoic acid. In an in vivo epicutaneous potassium iodide inflammation model, it was possible to demonstrate for the first time the anti-inflammatory action of 13-cis-retinoic acid.
本研究表明，重度痤疮的特征是存在众多炎症参数。痤疮四联症患者组在许多实验室检测指标上与聚合性痤疮患者不同。所有患者对13-顺式维甲酸治疗的耐受性良好。所有患者均出现皮脂分泌抑制和剥脱性唇炎，但无头痛和脱发。治疗期间，许多先前异常的血液化学指标恢复正常。转氨酶、碱性磷酸酶、甘油三酯和总胆固醇未见明显升高，毛发学和精液学参数未受13-顺式维甲酸影响。在体内表皮碘化钾炎症模型中，首次证实了13-顺式维甲酸的抗炎作用。
