Peck G L, Olsen T G, Yoder F W, Strauss J S, Downing D T, Pandya M, Butkus D, Arnaud-Battandier J
N Engl J Med. 1979 Feb 15;300(7):329-33. doi: 10.1056/NEJM197902153000701.
Fourteen patients with treatment-resistant cystic and conglobate acne were treated for four months with oral 13-cis-retinoic acid, a synthetic isomer of naturally occurring all-trans-retinoic acid. The average dose was 2.0 mg per kilogram per day. Thirteen patients experienced complete clearing of their disease; the other had 75 per cent improvement, as determined by the number of acne nodules and cysts present before and after therapy. Prolonged remissions, currently lasting as long as 20 months after discontinuation of therapy, have been observed in all 14 patients. Clinical toxicity was limited to the skin and mucous membranes in most patients and was dose dependent and rapidly reversible upon discontinuation of therapy. The mechanism of action of 13-cis-retinoic acid in the therapy of acne probably involves a direct inhibitory effect of the drug on the sebaceous gland.
14例难治性囊肿性聚合性痤疮患者接受了口服13-顺式维甲酸治疗4个月，13-顺式维甲酸是天然存在的全反式维甲酸的合成异构体。平均剂量为每日每公斤2.0毫克。13例患者病情完全缓解；另一例患者病情改善了75%，这是根据治疗前后痤疮结节和囊肿的数量确定的。在所有14例患者中均观察到了长期缓解，目前在停药后长达20个月。大多数患者的临床毒性仅限于皮肤和粘膜，且与剂量相关，停药后可迅速逆转。13-顺式维甲酸治疗痤疮的作用机制可能涉及该药物对皮脂腺的直接抑制作用。
