Adhami Z N, Wise R, Weston D, Crump B
J Antimicrob Chemother. 1984 Jan;13(1):87-92. doi: 10.1093/jac/13.1.87.
The pharmacokinetics and cantharides-induced blister fluid levels of norfloxacin were studied after a single 400 mg oral dose. The mean maximum serum level was 1.45 mg/l and occurred 1.5 h after administration. The serum half-life of norfloxacin was found to be 3.5 h. After 24 h 27% of the administered dose was recovered in the urine as microbiologically active compound. High urine levels were found. Rapid blister fluid penetration occurred, the maximum level (occurring between 2-3 h) was about 1 mg/l. Thereafter the blister fluid level exceeded the serum level, both declining in parallel.
单次口服400毫克诺氟沙星后，对其药代动力学及斑蝥素诱导水泡液中的诺氟沙星水平进行了研究。平均最大血清水平为1.45毫克/升，于给药后1.5小时出现。诺氟沙星的血清半衰期为3.5小时。24小时后，给药剂量的27%以具有微生物活性的化合物形式在尿液中回收。尿液中诺氟沙星水平较高。水泡液渗透迅速，最大水平（在2 - 3小时之间出现）约为1毫克/升。此后，水泡液水平超过血清水平，两者平行下降。
