Lockley M R, Wise R, Dent J
J Antimicrob Chemother. 1984 Dec;14(6):647-52. doi: 10.1093/jac/14.6.647.
The pharmacokinetics of the 4-quinolone agent, ofloxacin, were studied in six healthy volunteers, following a 600 mg oral dose. The levels of the compound were measured by a microbiological assay in serum, blister fluid and urine. The compound was rapidly absorbed, the mean maximum concentration of ofloxacin being 10.7 mg/l at 1.2 h. The mean serum elimination half-life was 7 h and 80.3% of the administered compound was recovered in the urine by 48 h. Ofloxacin penetrated the blister fluid well, the mean peak level being 5.2 mg/l at 5.3 h.
对6名健康志愿者口服600毫克4-喹诺酮类药物氧氟沙星后的药代动力学进行了研究。通过微生物测定法测定血清、水疱液和尿液中该化合物的水平。该化合物吸收迅速，氧氟沙星的平均最大浓度在1.2小时时为10.7毫克/升。血清平均消除半衰期为7小时，48小时内80.3%的给药化合物在尿液中回收。氧氟沙星能很好地渗透到水疱液中，平均峰值水平在5.3小时时为5.2毫克/升。
