Paige D M, Mellits E D, Chiu F Y, Davis L, Bayless T M, Cordano A
Am J Clin Nutr. 1978 Feb;31(2):222-5. doi: 10.1093/ajcn/31.2.222.
Lactose tolerance tests are used clinically to screen children and infants. It is assumed that absorption of a lactose challenge in infants would occur in a predictable pattern prior to weaning. Twenty-one infants from 3 to 12 months of age were studied. The maximum blood glucose rise over fasting levels ranged from 11.0 to 62.0 mg/100 ml; the mean was 32.6 mg/100 ml. Six infants had a maximum rise of less than 20 mg/100 ml. Eleven infants (52%) had a maximum rise of greater than 30 mg/100 ml. Signs of intolerance were not noted in any subject. Weight and length were normally disturbed. Results indicate the variance in glucose rise existing within a population of infants growing normally and consuming milk. Gastric emptying, digestion, and absorption may influence the blood glucose rise after a lactose test. Established glucose levels used as an index to lactose absorption in older children and adults may not accurately reflect lactase activity in infants.
乳糖耐量试验在临床上用于筛查儿童和婴儿。一般认为，在断奶前，婴儿对乳糖激发试验的吸收会呈现出可预测的模式。对21名3至12个月大的婴儿进行了研究。空腹血糖水平的最大升高幅度在11.0至62.0毫克/100毫升之间；平均值为32.6毫克/100毫升。6名婴儿的最大升高幅度小于20毫克/100毫升。11名婴儿（52%）的最大升高幅度大于30毫克/100毫升。在任何受试者中均未观察到不耐受的迹象。体重和身高均正常。结果表明，在正常生长并食用牛奶的婴儿群体中，血糖升高存在差异。胃排空、消化和吸收可能会影响乳糖试验后的血糖升高。在大龄儿童和成年人中用作乳糖吸收指标的既定血糖水平可能无法准确反映婴儿的乳糖酶活性。
