de Villiers F P
J Clin Gastroenterol. 1987 Jun;9(3):320-3. doi: 10.1097/00004836-198706000-00016.
Inability to hydrolyze lactose does not always cause symptoms. The lactose tolerance test commonly used in diagnosis pinpoints the biochemical anomaly but does not establish whether it causes a functional disability. I therefore compared a milk tolerance test (500 ml milk) with the standard lactose tolerance test in 40 healthy adult volunteers for rise in blood sugar. A maximum glucose rise of 9 mg/100 ml or less indicated lactose malabsorption. Only one subject was misclassified by the milk tolerance test when compared with the lactose tolerance test (specificity 91.7%; sensitivity 100%). The test not only reproduces the worst symptoms that the subject is likely to suffer due to usual milk intake, but also accurately identifies the lactose malabsorber, thus yielding more information than the standard lactose tolerance test.
无法水解乳糖并不一定会引发症状。诊断中常用的乳糖耐量试验能精准找出生化异常情况，但无法确定其是否会导致功能障碍。因此，我在40名健康成年志愿者中，比较了牛奶耐量试验（500毫升牛奶）和标准乳糖耐量试验对血糖升高的影响。血糖最大升高幅度为9毫克/100毫升或更低表明乳糖吸收不良。与乳糖耐量试验相比，牛奶耐量试验仅将一名受试者误分类（特异性91.7%；敏感性100%）。该试验不仅能重现受试者因日常摄入牛奶可能出现的最严重症状，还能准确识别出乳糖吸收不良者，因此比标准乳糖耐量试验能提供更多信息。
