Borriello S P
Scand J Gastroenterol Suppl. 1984;93:115-21.
The composition of the flora of the large bowel is extremely complex, as are the combination of factors involved in its control. As would be expected, although the host affects the gut flora, equally the gut flora affects the host. One of the results of this interplay is that subtle changes can lead to a marked effect on the host resulting in disease. It is now well established that bacteria can alter both secretion and motility of the gastrointestinal tract. However the effect on both of these functions has been best studied in the small bowel, this being especially true for studies on motility. In order to appreciate fully the complexity of the situation and to understand the activities of the flora that can modify gut function a brief overview of the flora of the gastrointestinal tract in health and disease and the factors involved in its regulation will be given. This will be followed by a general description of the effects of this flora on the gut, and a specific account of how large bowel motility and secretion can be altered.
大肠菌群的组成极其复杂，其调控所涉及的因素组合也是如此。正如所预期的那样，尽管宿主会影响肠道菌群，但同样地，肠道菌群也会影响宿主。这种相互作用的结果之一是，细微的变化可能会对宿主产生显著影响，从而导致疾病。现在已经充分证实，细菌可以改变胃肠道的分泌和运动。然而，对这两种功能的影响在小肠中研究得最为充分，在运动方面的研究尤其如此。为了充分认识这种情况的复杂性，并了解能够改变肠道功能的菌群活动，将简要概述健康和疾病状态下胃肠道的菌群以及其调节所涉及的因素。接下来将对这种菌群对肠道的影响进行一般性描述，并具体说明大肠的运动和分泌是如何被改变的。
