Perez G O, Glasson P, Favre H, Wauters J P, Benzonana G, Jeannet M, Lambert P H
Am J Nephrol. 1984;4(4):215-21. doi: 10.1159/000166812.
The prevalence of circulating immune complexes (CIC) was investigated using the C1q binding assay (C1q BA) and the conglutinin binding assay (Kg BA) in 200 patients undergoing maintenance hemodialysis. Increased C1q binding was found in 45% (87 of 194) of the patients, and the modified Kg BA gave elevated values in 31% (20 of 65). The prevalence of CIC was similar in American and Swiss patients, and in patients undergoing hemodialysis, self-dialysis or peritoneal dialysis. In patients with 'nonimmunological' renal diseases, CIC were detected with similar frequency. No change in CIC was noted during hemodialysis in 6 additional patients tested. The abnormality was not related to age, sex, duration of dialysis, hepatitis B antigenemia, bacterial infections, or transfusions. Anti-DNA antibodies were absent in all subjects tested and the results of the C1q BA were not changed by DNase digestion of eight sera with high C1q binding. Rheumatoid factor activity (RF) was detected in approximately one-fifth of the patients, and there was a direct correlation between positive C1q binding and RF. There was no correlation between CIC and lymphocytotoxic antibodies. This study demonstrated a high prevalence of CIC in dialyzed uremic patients and established its relationship to other immunological abnormalities.
采用C1q结合试验（C1q BA）和胶固素结合试验（Kg BA）对200例维持性血液透析患者循环免疫复合物（CIC）的患病率进行了研究。在194例患者中有45%（87例）发现C1q结合增加，改良的Kg BA在65例患者中有31%（20例）出现升高值。美国和瑞士患者以及接受血液透析、自体透析或腹膜透析的患者中CIC的患病率相似。在患有“非免疫性”肾脏疾病的患者中，检测到CIC的频率相似。在另外6例接受检测的患者血液透析期间，未发现CIC有变化。这种异常与年龄、性别、透析时间、乙肝抗原血症、细菌感染或输血无关。所有检测对象均未检测到抗DNA抗体，用DNase消化8份C1q结合率高的血清后，C1q BA的结果未发生变化。约五分之一的患者检测到类风湿因子活性（RF），C1q结合阳性与RF之间存在直接相关性。CIC与淋巴细胞毒性抗体之间无相关性。本研究表明，透析的尿毒症患者中CIC的患病率很高，并确定了其与其他免疫异常的关系。
