给人类志愿者单次口服给药后粪便中诺氟沙星的回收率。
Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers.
作者信息
Cofsky R D, duBouchet L, Landesman S H
出版信息
Antimicrob Agents Chemother. 1984 Jul;26(1):110-1. doi: 10.1128/AAC.26.1.110.
Abstract
Twelve healthy volunteers received single 400-mg oral doses of norfloxacin. During the ensuing 48 h, from 8.3 to 53.3% (mean, 28%) of this dose was recovered in the feces. Peak drug concentrations in fecal specimens ranged from 207 to 2,716 micrograms/g.
摘要
12名健康志愿者口服了400毫克的诺氟沙星单剂量。在随后的48小时内，该剂量的8.3%至53.3%（平均为28%）在粪便中被回收。粪便样本中的药物峰值浓度在207至2716微克/克之间。
相似文献
1
Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers.
Antimicrob Agents Chemother. 1984 Jul;26(1):110-1. doi: 10.1128/AAC.26.1.110.
2
Norfloxacin disposition after sequentially increasing oral doses.
Antimicrob Agents Chemother. 1983 Feb;23(2):284-8. doi: 10.1128/AAC.23.2.284.
3
Norfloxacin for selective decontamination: a study in human volunteers.
Prog Clin Biol Res. 1985;181:259-62.
4
The pharmacokinetics and tissue penetration of enoxacin and norfloxacin.
J Antimicrob Chemother. 1984 Sep;14 Suppl C:75-81. doi: 10.1093/jac/14.suppl_c.75.
5
The pharmacokinetics and tissue penetration of norfloxacin.
J Antimicrob Chemother. 1984 Jan;13(1):87-92. doi: 10.1093/jac/13.1.87.
6
Pharmacokinetic studies of norfloxacin in laboratory animals.
Chemotherapy. 1984;30(5):288-96. doi: 10.1159/000238283.
7
Pharmacokinetics of norfloxacin (MK 366) in patients with impaired kidney function--some preliminary results.
J Antimicrob Chemother. 1984 May;13 Suppl B:55-7. doi: 10.1093/jac/13.suppl_b.55.
8
Pharmacokinetics of norfloxacin in healthy volunteers and patients with renal and hepatic damage.
Eur J Clin Microbiol. 1983 Jun;2(3):253-9. doi: 10.1007/BF02029528.
9
Selective decontamination of the digestive tract by norfloxacin. A preliminary report.
Prog Clin Biol Res. 1985;181:255-8.
10
Recovery of pefloxacin in saliva and feces and its action on oral and fecal floras of healthy volunteers.
Antimicrob Agents Chemother. 1987 Nov;31(11):1665-8. doi: 10.1128/AAC.31.11.1665.
引用本文的文献
1
Effect of Tinidazole on Norfloxacin Disposition.
Iran J Pharm Res. 2017 Fall;16(4):1574-1582.
2
In vitro antimicrobial susceptibility of bacterial enteropathogens isolated from international travelers to Mexico, Guatemala, and India from 2006 to 2008.
Antimicrob Agents Chemother. 2011 Feb;55(2):874-8. doi: 10.1128/AAC.00739-10. Epub 2010 Nov 29.
3
Daily norfloxacin is more effective than weekly rufloxacin in prevention of spontaneous bacterial peritonitis recurrence.
Dig Dis Sci. 2002 Jun;47(6):1356-61. doi: 10.1023/a:1015386901343.
4
Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers.
Antimicrob Agents Chemother. 2001 Feb;45(2):608-11. doi: 10.1128/AAC.45.2.608-611.2001.
5
Use of the quinolones for the prophylaxis and therapy of infections in immunocompromised hosts.
Drugs. 1993;45 Suppl 3:73-80. doi: 10.2165/00003495-199300453-00014.
6
Impact of the fluoroquinolones on gastrointestinal flora.
Drugs. 1993;45 Suppl 3:125-33. doi: 10.2165/00003495-199300453-00021.
7
Quinolones in Salmonella typhi infection.
Drugs. 1993;45 Suppl 3:119-24. doi: 10.2165/00003495-199300453-00020.
8
Quinolones in the treatment of acute bacterial diarrhoeal diseases.
Drugs. 1993;45 Suppl 3:114-8. doi: 10.2165/00003495-199300453-00019.
9
In vitro susceptibility of pathogenic Vibrio species to norfloxacin and six other antimicrobial agents.
Antimicrob Agents Chemother. 1985 Sep;28(3):442-5. doi: 10.1128/AAC.28.3.442.
10
Comparative in vitro activities of selected antimicrobial agents against Aeromonas species and Plesiomonas shigelloides.
Antimicrob Agents Chemother. 1985 Apr;27(4):643-5. doi: 10.1128/AAC.27.4.643.
本文引用的文献
1
In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens.
Antimicrob Agents Chemother. 1983 Jan;23(1):86-90. doi: 10.1128/AAC.23.1.86.
2
Antibacterial activity of norfloxacin.
Antimicrob Agents Chemother. 1983 Jan;23(1):15-8. doi: 10.1128/AAC.23.1.15.
3
In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.
Antimicrob Agents Chemother. 1982 Jul;22(1):23-7. doi: 10.1128/AAC.22.1.23.
4
Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolates.
Antimicrob Agents Chemother. 1982 May;21(5):848-51. doi: 10.1128/AAC.21.5.848.
5
In vitro antibacterial activity of norfloxacin (MK-0366).
Antimicrob Agents Chemother. 1982 Apr;21(4):604-7. doi: 10.1128/AAC.21.4.604.
Zotero 插件