给人类志愿者单次口服给药后粪便中诺氟沙星的回收率。
Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers.
作者信息
Cofsky R D, duBouchet L, Landesman S H
出版信息
Antimicrob Agents Chemother. 1984 Jul;26(1):110-1. doi: 10.1128/AAC.26.1.110.
Abstract
Twelve healthy volunteers received single 400-mg oral doses of norfloxacin. During the ensuing 48 h, from 8.3 to 53.3% (mean, 28%) of this dose was recovered in the feces. Peak drug concentrations in fecal specimens ranged from 207 to 2,716 micrograms/g.
摘要
12名健康志愿者口服了400毫克的诺氟沙星单剂量。在随后的48小时内，该剂量的8.3%至53.3%（平均为28%）在粪便中被回收。粪便样本中的药物峰值浓度在207至2716微克/克之间。
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