十二指肠-胰腺分泌物可增强抗菌药物的杀菌活性。
Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs.
作者信息
Mett H, Gyr K, Zak O, Vosbeck K
出版信息
Antimicrob Agents Chemother. 1984 Jul;26(1):35-8. doi: 10.1128/AAC.26.1.35.
Abstract
We have studied the action of various antimicrobial agents in microbiological media and in human duodeno-pancreatic secretions. In the latter medium, clioquinol exhibited a rapid bactericidal effect on both growing and stationary bacteria at concentrations near its MIC. However, it was merely bacteriostatic in microbiological media, even at high concentrations. Phanquinone, chlorquinaldol, and, to a lesser extent, also chloramphenicol and trimethoprim likewise displayed enhanced bactericidal activity in duodeno-pancreatic secretions, but various other antibacterial agents did not. These findings suggest that duodeno-pancreatic secretions contain a factor augmenting the antibacterial activity of a number of drugs.
摘要
我们研究了多种抗菌剂在微生物培养基和人十二指肠-胰液中的作用。在后一种培养基中，氯碘羟喹在接近其最低抑菌浓度的浓度下，对生长和静止期细菌均表现出快速杀菌作用。然而，即使在高浓度下，它在微生物培养基中也仅具有抑菌作用。泛醌、氯喹那多，以及在较小程度上的氯霉素和甲氧苄啶，同样在十二指肠-胰液中表现出增强的杀菌活性，但其他各种抗菌剂则没有。这些发现表明，十二指肠-胰液中含有一种可增强多种药物抗菌活性的因子。
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本文引用的文献
1
[Clinical experiences with an intestinal disinfectant free of side-effects].
Wien Med Wochenschr. 1959 Dec 12;109:1007-9.
2
Comparative effects of synthetic and natural secretin on pancreatic secretion and on secretin, insulin, and glucagon levels in man.合成促胰液素与天然促胰液素对人体胰腺分泌以及促胰液素、胰岛素和胰高血糖素水平的比较作用。
Dig Dis Sci. 1982 Mar;27(3):231-3. doi: 10.1007/BF01296921.
3
Bicyclomycin, a new antibiotic. 3. In vitro and in vivo antimicrobial activity.双环霉素，一种新型抗生素。3. 体外和体内抗菌活性。
J Antibiot (Tokyo). 1972 Oct;25(10):582-93.
4
Isolation and characterization of a phosphonomycin-resistant mutant of Escherichia coli K-12.大肠杆菌K-12磷霉素抗性突变体的分离与鉴定
J Bacteriol. 1972 Jun;110(3):935-44. doi: 10.1128/jb.110.3.935-944.1972.
5
[The treatment of dysbiotic intestinal disorders with Mexaform S].[使用Mexaform S治疗肠道菌群失调症]
Med Welt. 1965 Jul 17;29:1660-3.
6
Antimicrobial spectrum of triclosan, a broad-spectrum antimicrobial agent for topical application. II. Comparison with some other antimicrobial agents.
Dermatologica. 1979;158(1):72-9. doi: 10.1159/000250746.
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