Brouwers P, Cox C, Martin A, Chase T, Fedio P
Arch Neurol. 1984 Oct;41(10):1073-6. doi: 10.1001/archneur.1984.04050210071017.
Because the severity of memory disorders exhibited by neuropsychiatric patients overshadows other cognitive deficiencies, we explored the visuoperceptual and constructive abilities of patients with Alzheimer's (AD) or Huntington's (HD) disease. The tasks assessed directional sense with reference to egocentric space, as well as visuodiscriminative and constructive skills of patients and matched controls. A double dissociation was found: the performance of patients with AD was found to be significantly impaired on tasks involving extrapersonal perception and construction but not on the test of egocentric space. In contrast, visuoconstructive performance by patients with HD was not significantly impaired, while salient deficits were apparent when manipulation of personal space was required. These differential patterns of defects may have been aligned with neuropathologic changes in different cortical and subcortical structures, respectively, in patients with AD and HD.
由于神经精神疾病患者所表现出的记忆障碍的严重程度掩盖了其他认知缺陷，我们研究了阿尔茨海默病（AD）或亨廷顿病（HD）患者的视觉感知和建构能力。这些任务评估了相对于自我中心空间的方向感，以及患者和匹配对照组的视觉辨别和建构技能。我们发现了一种双重分离现象：AD患者在涉及个人空间外感知和建构的任务上表现显著受损，但在自我中心空间测试中则不然。相比之下，HD患者的视觉建构表现没有显著受损，而在需要操作个人空间时则出现明显缺陷。这些不同的缺陷模式可能分别与AD和HD患者不同皮质和皮质下结构的神经病理变化有关。
