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阿尔茨海默病、亨廷顿舞蹈症和酒精性柯萨科夫综合征患者记忆丧失的差异模式。

Differential patterns of memory loss among patients with Alzheimer's disease, Huntington's disease, and alcoholic Korsakoff's syndrome.

作者信息

Moss M B, Albert M S, Butters N, Payne M

出版信息

Arch Neurol. 1986 Mar;43(3):239-46. doi: 10.1001/archneur.1986.00520030031008.

DOI:10.1001/archneur.1986.00520030031008
PMID:2936323
Abstract

Patients with Huntington's disease (HD), alcoholic Korsakoff's syndrome (KS), and Alzheimer's disease (AD) were compared with normal control subjects on a task designed to assess recognition memory for different classes of stimuli: spatial, verbal, color, pattern, and facial. In addition, recall of verbal stimuli was assessed at two delay intervals. On recognition testing, AD and KS patients were impaired on each of the five stimulus conditions. However, HD patients, though impaired on four of the recognition conditions, were unimpaired when verbal stimuli were used. On recall testing, the AD, HD, and KS groups were equally impaired at the shorter delay (15 s). However, at the longer delay (two minutes), the KS and HD patients, though still impaired relative to the normal control group, performed significantly better than the AD group.

摘要

对患有亨廷顿舞蹈症(HD)、酒精性柯萨科夫综合征(KS)和阿尔茨海默病(AD)的患者与正常对照受试者进行了一项任务比较,该任务旨在评估对不同类型刺激的识别记忆,包括空间、言语、颜色、图案和面部刺激。此外,还在两个延迟间隔评估了言语刺激的回忆情况。在识别测试中,AD和KS患者在所有五种刺激条件下均表现受损。然而,HD患者虽然在四种识别条件下表现受损,但在使用言语刺激时未受损。在回忆测试中,AD、HD和KS组在较短延迟(15秒)时受损程度相同。然而,在较长延迟(两分钟)时,KS和HD患者虽然相对于正常对照组仍有受损,但表现明显优于AD组。

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