[丁醇、辛醇、乙醛和巴豆醛对人体皮肤刺激性作用的定量测定]
[Quantitative determination of the irritating effect on human skin of butanol, octanol, acetaldehyde and crotonaldehyde].
作者信息
Baĭnova A, Madzhunov N
出版信息
Probl Khig. 1984;9:66-72.
A method was elaborated for quantitative assessment of the irritating effect of the solvents after a 24-hour contact with healthy subjects. The irritating effect of octanol is weaker, with statistical significance, than that of butanol. Croton aldehyde proved to be the strongest irritator. The threshold skin irritating concentrations are 12% octanol, 7.8% butanol, 1.2% acetaldehyde and 0.12% croton aldehyde in plant oil. The following allergic concentrations in plant oil are recommended for epicutaneous testing of subjects with occupational or every day home contact allergy versus paints, varnishes, glues, cleaning and defatting agents and anticorrosive preparations: 6% octanol, 4% butanol, 0.6% acetaldehyde and 0.06% croton aldehyde.
阐述了一种用于定量评估溶剂与健康受试者接触24小时后刺激作用的方法。辛醇的刺激作用比丁醇弱，具有统计学意义。巴豆醛被证明是最强的刺激物。植物油中辛醇、丁醇、乙醛和巴豆醛的皮肤刺激阈浓度分别为12%、7.8%、1.2%和0.12%。对于职业性或日常家庭接触性过敏的受试者，与油漆、清漆、胶水、清洁和脱脂剂以及防腐剂进行皮试时，推荐植物油中的以下过敏浓度：6%辛醇、4%丁醇、0.6%乙醛和0.06%巴豆醛。
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