Goodwin J S
Am J Med. 1984 Oct 15;77(4B):7-15. doi: 10.1016/s0002-9343(84)80086-8.
Recent studies of the immunoregulatory effects of prostaglandin and the immunomodulating actions of nonsteroidal anti-inflammatory drugs reveal that earlier reports of inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs cannot alone fully explain the anti-inflammatory properties of these agents. Data defining the complex inter-relationship of prostaglandin, the immune response, and nonsteroidal anti-inflammatory drugs are reviewed, and possible mechanisms of anti-inflammatory action of these agents are considered. The effects of nonsteroidal anti-inflammatory drugs on cellular immune function and humoral immune response suggest that anti-inflammatory activity may be related to altered suppressor cell function, inhibition of monocyte collagenase release, or inhibition of neutrophil migration and activation. Further elucidation is awaited.
近期关于前列腺素免疫调节作用及非甾体抗炎药免疫调节作用的研究表明，早期有关非甾体抗炎药抑制前列腺素合成的报道并不能完全解释这些药物的抗炎特性。本文综述了有关前列腺素、免疫反应及非甾体抗炎药之间复杂相互关系的数据，并探讨了这些药物抗炎作用的可能机制。非甾体抗炎药对细胞免疫功能和体液免疫反应的影响表明，抗炎活性可能与抑制性细胞功能改变、单核细胞胶原酶释放受抑或中性粒细胞迁移和活化受抑有关。有待进一步阐明。
