Rubinstein A, Sicklick M, Gupta A, Bernstein L, Klein N, Rubinstein E, Spigland I, Fruchter L, Litman N, Lee H, Hollander M
JAMA. 1983 May 6;249(17):2350-6.
A new syndrome of acquired immunodeficiency has been identified in seven children who were small for gestational age at birth and subsequently have exhibited failure to thrive, lymphadenopathy, parotitis, hepatosplenomegaly, interstitial pneumonia, and recurrent infections. All have a profound cell-mediated immunodeficiency with reversed T4/T8 ratios. Six are hypergammaglobulinemic and one has low IgG levels. The mothers of five of the seven children are sexually promiscuous and/or drug addicts. Three mothers have an immunodeficiency similar to that found in their infants. One of them died at age 33 years with a diagnosis of acquired immunodeficiency syndrome. In five of the children and in three of their mothers, there is evidence of a persistent Epstein-Barr virus (EBV) infection. We speculate that a perinatal or in utero transmission of EBV can induce an "infectious immunodeficiency." The clinical, histopathologic, and immunologic features resemble those described in adult homosexuals and drug addicts.
在7名出生时小于胎龄、随后出现生长发育迟缓、淋巴结病、腮腺炎、肝脾肿大、间质性肺炎和反复感染的儿童中，发现了一种新的获得性免疫缺陷综合征。所有患儿均有严重的细胞介导免疫缺陷，T4/T8比值倒置。6名患儿高丙种球蛋白血症，1名患儿IgG水平低。7名患儿中有5名的母亲有性乱行为和/或吸毒成瘾。3名母亲有与其婴儿相似的免疫缺陷。其中1名母亲33岁时死于获得性免疫缺陷综合征。在5名患儿及其3名母亲中，有证据表明存在持续性EB病毒（EBV）感染。我们推测，EBV的围产期或宫内传播可诱发“感染性免疫缺陷”。其临床、组织病理学和免疫学特征与成年同性恋者和吸毒成瘾者中所描述的相似。
