Bernstein D, Frishman H B, Levin S, Schwartz S
Fertil Steril. 1978 Feb;29(2):141-3. doi: 10.1016/s0015-0282(16)43089-x.
Urine samples from 76 pregnant women were tested for pregnanediol content during the first 6 weeks of pregnancy. Pregnanediol was measured by gas chromatography in 24-hour urine samples obtained once weekly from 76 randomly selected pregnant women 21, 28, 35, and 42 days after the last menstrual period. Pregnancy was ascertained by a positive hemagglutination inhibition test for human chorionic gonadotropin. In patients in whom the urinary pregnanediol content was less than 3 mg/24 hours the abortion rate was 81.5%, and 18.5% had normal pregnancies and births In patients whose pregnanediol content was greater than 3 mg/24 hours the abortion rate was 8.3%, and 91.7% had normal pregnancies and births. The 24-hour urinary pregnanediol excretion rate reflects corpus luteum function and can be considered as a means of monitoring pregnancy in its initial stage.
对76名孕妇妊娠头6周的尿液样本进行孕二醇含量检测。从76名随机选择的孕妇末次月经后21天、28天、35天和42天每周采集一次24小时尿液样本，采用气相色谱法测定孕二醇含量。通过人绒毛膜促性腺激素的血凝抑制试验阳性来确定妊娠。尿中孕二醇含量低于3mg/24小时的患者流产率为81.5%，18.5%有正常妊娠和分娩；孕二醇含量高于3mg/24小时的患者流产率为8.3%，91.7%有正常妊娠和分娩。24小时尿孕二醇排泄率反映黄体功能，可作为妊娠初期监测手段。
