阿昔洛韦对接种单纯疱疹病毒的仓鼠中枢神经系统感染的预防和治疗作用

Preventive and curative effects of acyclovir on central nervous system infections in hamsters inoculated with herpes simplex virus.

作者信息

van Ekdom L T, Versteeg J

出版信息

Am J Med. 1982 Jul 20;73(1A):161-4. doi: 10.1016/0002-9343(82)90083-3.

Abstract

Hamsters are very susceptible to infections with herpes simplex virus. Inoculation of the skin of the lower back region leads to an ascending involvement of the central nervous system with fatal outcome. This model was used for testing the activity of antiviral substances in herpes infections of the nervous system. Acyclovir given in optimal dosages prevented infection of the central nervous system completely even when therapy was started 48 hours after inoculation. Therapy with acyclovir proved to be successful in animals showing paresis after infection even when the drug was given in lower than optimal dosages.

摘要

仓鼠对单纯疱疹病毒感染非常敏感。接种下背部皮肤会导致中枢神经系统上行性受累并导致致命后果。该模型用于测试抗病毒物质在神经系统疱疹感染中的活性。即使在接种后48小时开始治疗，以最佳剂量给予阿昔洛韦也能完全预防中枢神经系统感染。事实证明，即使给予低于最佳剂量的药物，对感染后出现轻瘫的动物进行阿昔洛韦治疗也是成功的。