无环鸟苷治疗小鼠急性和潜伏性单纯疱疹感染的效果。
Effect of acycloguanosine treatment of acute and latent herpes simplex infections in mice.
作者信息
Field H J, Bell S E, Elion G B, Nash A A, Wildy P
出版信息
Antimicrob Agents Chemother. 1979 Apr;15(4):554-61. doi: 10.1128/AAC.15.4.554.
Abstract
Systemic treatment of mice with the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine [aciclovir]) was found to be highly effective against acute type 1 herpes simplex virus infection of the pinna. The drug ablated clinical signs and reduced virus replication both in tissue local to the inoculation site and within the nervous system. Provided that moderate-sized virus inocula were used, acycloguanosine treatment reduced or prevented the establishment of a latent infection in the dorsal root ganglia relating to the sensory nerve supply of the ear. However, although it aborted artificially produced infections in dorsal root ganglia, acycloguanosine was found not to be effective against the latent infection once established. This finding strongly indicated that latent herpes simplex virus in mice can exist in a nonreplicating form.
摘要
用核苷类似物9-(2-羟乙氧甲基)鸟嘌呤（无环鸟苷[阿昔洛韦]）对小鼠进行全身治疗，发现对耳廓急性1型单纯疱疹病毒感染非常有效。该药物消除了临床症状，并减少了接种部位局部组织和神经系统内的病毒复制。如果使用中等大小的病毒接种物，无环鸟苷治疗可减少或预防与耳部感觉神经供应相关的背根神经节中潜伏感染的建立。然而，尽管它能中止背根神经节中人工产生的感染，但一旦潜伏感染建立，无环鸟苷就被发现对其无效。这一发现有力地表明，小鼠体内的潜伏单纯疱疹病毒可以以非复制形式存在。
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